Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.774


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
Tal1 21349 T-cell acute lymphocytic leukemia 1
Tcf12 21406 transcription factor 12
Tcf3 21423 transcription factor 3
Tcf4 21413 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4chr18_+_698437300.121.1e-01Click!
Tcf3chr10_-_798960860.045.5e-01Click!
Tcf12chr9_-_719595990.046.1e-01Click!
Tal1chr4_+_114732112-0.037.0e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_133591146 16.907 Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr11_+_101192080 13.233 Aoc3
amine oxidase, copper containing 3
chr5_-_17394776 12.319 NM_001159558
Cd36
CD36 antigen
chr7_+_31561419 12.291 NM_028618
Dmkn
dermokine
chr11_-_5703752 11.779 NM_018870
Pgam2
phosphoglycerate mutase 2
chr18_+_44122894 10.919 NM_001081180
Spink5
serine peptidase inhibitor, Kazal type 5
chr2_+_35159780 10.867 Gsn
gelsolin
chr2_+_158328394 10.066 Adig
adipogenin
chr1_+_196765124 10.030 Cd34
CD34 antigen
chr1_+_196765014 9.384 NM_001111059
NM_133654
Cd34

CD34 antigen

chr1_+_196765079 8.716 Cd34
CD34 antigen
chr2_+_158328317 8.336 NM_145635
Adig
adipogenin
chr11_-_5703677 7.849 Pgam2
phosphoglycerate mutase 2
chr8_-_109589522 6.679 NM_025458
Tmed6
transmembrane emp24 protein transport domain containing 6
chr5_-_17394564 6.637 Cd36
CD36 antigen
chr7_+_28856254 6.361 NM_001122603
Fcgbp
Fc fragment of IgG binding protein
chr14_+_120674921 6.351 Mbnl2
muscleblind-like 2
chr14_+_120674886 6.272 NM_175341
NM_207515
Mbnl2

muscleblind-like 2

chr14_+_120674933 6.269 Mbnl2
muscleblind-like 2
chr2_-_79969095 5.582 NM_016744
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr4_-_148829073 5.043 NM_022020
Rbp7
retinol binding protein 7, cellular
chr14_+_120674913 4.996 Mbnl2
muscleblind-like 2
chr8_-_126417352 4.929 Acta1
actin, alpha 1, skeletal muscle
chr9_-_15105864 4.690 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr14_+_120674939 4.419 Mbnl2
muscleblind-like 2
chr1_+_45402907 4.318 Col3a1
collagen, type III, alpha 1
chr8_-_11199802 4.305 Col4a1
collagen, type IV, alpha 1
chr9_-_15105965 4.249 NM_133732
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr2_-_122436933 4.201 NM_025961
Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_-_75106702 4.104 NM_001162913
NM_027890
Susd2

sushi domain containing 2

chr15_+_58770843 3.480 Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr3_-_8964045 3.479 NM_001025261
NM_001025262
Tpd52

tumor protein D52

chr18_-_34738725 3.469 NM_080637
Nme5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr1_-_164796609 3.450 Fmo1
flavin containing monooxygenase 1
chr17_+_24864773 3.411 NM_001163945
Rpl3l
ribosomal protein L3-like
chrX_+_68809128 3.355 Hmgb3
high mobility group box 3
chr1_-_164796660 3.164 NM_010231
Fmo1
flavin containing monooxygenase 1
chr11_+_67611772 3.125 NM_001013013
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr5_-_44485951 3.091 NM_001163578
NM_001163581
NM_001163582
NM_001163583
NM_001163584
NM_001163585
Prom1





prominin 1





chr5_+_130263548 3.059 Gbas
glioblastoma amplified sequence
chr9_+_114373337 2.944 Glb1
galactosidase, beta 1
chr7_+_147949637 2.938 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr3_+_19869841 2.927 Cp
ceruloplasmin
chr4_+_118199847 2.886 NM_025572
2610528J11Rik
RIKEN cDNA 2610528J11 gene
chr7_+_51480806 2.866 NM_010639
Klk1
kallikrein 1
chr11_+_96205082 2.844 NM_010458
Hoxb3
homeobox B3
chr11_+_93905501 2.774 NM_001025428
NM_001025429
NM_001025430
Spag9


sperm associated antigen 9


chr15_+_78859949 2.770


chr14_-_35401845 2.741 NM_001039071
NM_001039072
NM_001039073
NM_001039075
NM_001039076
NM_011918
Ldb3





LIM domain binding 3





chr1_-_195090178 2.726 NM_008288
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr7_+_138087002 2.542 Htra1
HtrA serine peptidase 1
chr6_-_38787222 2.540 NM_001136065
Hipk2
homeodomain interacting protein kinase 2
chr4_+_148913978 2.523 Ctnnbip1
catenin beta interacting protein 1
chr17_+_75578120 2.517 NM_206958
Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_109088251 2.489 NM_001145948
Ttc39a
tetratricopeptide repeat domain 39A
chr7_+_27904997 2.422 Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr11_+_102697609 2.412 NM_080846
Higd1b
HIG1 domain family, member 1B
chr11_+_83560497 2.228 1100001G20Rik
RIKEN cDNA 1100001G20 gene
chr11_+_96790581 2.225 NM_146026
Prr15l
proline rich 15-like
chr1_+_133534852 2.212 NM_007799
Ctse
cathepsin E
chr6_+_5340417 2.181 Asb4
ankyrin repeat and SOCS box-containing 4
chr15_+_78860043 2.168 H1f0
H1 histone family, member 0
chr7_+_28902406 2.139 Fcgbp
Fc fragment of IgG binding protein
chr7_+_28914482 2.138 NM_001164655
9530053A07Rik
RIKEN cDNA 9530053A07 gene
chr1_+_34356614 2.138 Dst
dystonin
chr14_-_104213981 2.087


chr17_-_11033034 2.053 NM_027032
Pacrg
PARK2 co-regulated
chr12_-_102988596 2.052


chrX_+_68809103 2.045 Hmgb3
high mobility group box 3
chr16_+_16213397 2.038 Pkp2
plakophilin 2
chr11_+_93905443 2.021 Spag9
sperm associated antigen 9
chr6_+_122902850 1.960 Clec4a3
C-type lectin domain family 4, member a3
chr4_+_80556574 1.941 NM_026821
D4Bwg0951e
DNA segment, Chr 4, Brigham & Women's Genetics 0951 expressed
chr11_+_83560437 1.930 NM_183249
1100001G20Rik
RIKEN cDNA 1100001G20 gene
chr6_+_122902755 1.896 Clec4a3
C-type lectin domain family 4, member a3
chr11_+_29592897 1.855 NM_194052
NM_194053
NM_194054
Rtn4


reticulon 4


chr6_+_4471231 1.835 Col1a2
collagen, type I, alpha 2
chr9_+_77961211 1.827 Ick
intestinal cell kinase
chr1_+_90034940 1.784 Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr4_-_40883509 1.727 Bag1
BCL2-associated athanogene 1
chr6_+_122902532 1.713 NM_153197
Clec4a3
C-type lectin domain family 4, member a3
chr10_-_87937335 1.710 Chpt1
choline phosphotransferase 1
chr3_+_108163704 1.696 Sort1
sortilin 1
chr1_+_132628552 1.679 NM_177604
AA986860
expressed sequence AA986860
chr4_+_94405963 1.653 NM_013690
Tek
endothelial-specific receptor tyrosine kinase
chrX_+_68809092 1.625 Hmgb3
high mobility group box 3
chr9_-_66891535 1.623 NM_001164252
NM_001164253
NM_001164254
NM_001164256
Tpm1



tropomyosin 1, alpha



chr11_+_120537974 1.605 NM_001164224
NM_198223
Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chrX_-_100958883 1.602 NM_001170979
Gm6222
predicted pseudogene 6222
chr17_-_28536156 1.590 Fkbp5
FK506 binding protein 5
chr7_-_26262552 1.589 NM_001039185
NM_001039186
NM_001039187
NM_011926
Ceacam1



carcinoembryonic antigen-related cell adhesion molecule 1



chr11_-_3817574 1.566 Tcn2
transcobalamin 2
chr19_-_40525876 1.498 NM_001034962
NM_001034963
Sorbs1

sorbin and SH3 domain containing 1

chr15_+_78860623 1.480


chr3_+_101949321 1.421 Casq2
calsequestrin 2
chr3_-_95110715 1.394 NM_001085383
Anxa9
annexin A9
chr18_-_12978106 1.381 Osbpl1a
oxysterol binding protein-like 1A
chr5_+_23907911 1.371 Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr1_+_137732961 1.365 NM_001130174
NM_001130175
NM_001130177
NM_001130178
NM_001130179
NM_001130180
NM_001130181
NM_011619
NM_001136083
Tnnt2








troponin T2, cardiac








chr17_-_45724536 1.329 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr15_-_89307854 1.277 NM_009713
Arsa
arylsulfatase A
chr3_+_93123668 1.275 NM_133698
Hrnr
hornerin
chr2_-_164008333 1.255 NM_145369
Wfdc5
WAP four-disulfide core domain 5
chr16_+_18052952 1.243 NM_010047
Dgcr6
DiGeorge syndrome critical region gene 6
chrX_+_53708015 1.233 NM_172779
Ddx26b
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr7_-_26324847 1.174 NM_001113368
NM_001113369
NM_007543
Ceacam2


carcinoembryonic antigen-related cell adhesion molecule 2


chr7_+_25378887 1.150 Ethe1
ethylmalonic encephalopathy 1
chr1_+_137732910 1.148 Tnnt2
troponin T2, cardiac
chr13_-_23677831 1.128 Hist1h2be
histone cluster 1, H2be
chr1_+_164569335 1.124 Myoc
myocilin
chr2_-_25477449 1.082 NM_001040130
NM_001109993
Tmem141

transmembrane protein 141

chr8_+_131028275 1.075 Nrp1
neuropilin 1
chr17_-_31281184 1.074 Tff2
trefoil factor 2 (spasmolytic protein 1)
chr4_+_57867433 1.070 NM_001035533
Akap2
A kinase (PRKA) anchor protein 2
chr7_+_27904981 1.038 Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr1_-_71642303 1.010 Fn1
fibronectin 1
chr14_+_56236989 0.995 NM_020002
Rec8
REC8 homolog (yeast)
chr6_-_40985505 0.988 NM_023333
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr3_-_95111053 0.986 NM_023628
Anxa9
annexin A9
chr16_-_31314534 0.984 NM_007470
Apod
apolipoprotein D
chr9_+_32031833 0.970 NM_177379
Arhgap32
Rho GTPase activating protein 32
chr7_-_147288242 0.960 1810014F10Rik
RIKEN cDNA 1810014F10 gene
chr3_-_126701367 0.954 NM_178655
Ank2
ankyrin 2, brain
chr3_-_105746740 0.953 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr12_-_102988510 0.950 Fbln5
fibulin 5
chr19_-_23522811 0.937 NM_174857
Mamdc2
MAM domain containing 2
chr1_+_97230610 0.933 Fam174a
family with sequence similarity 174, member A
chr2_+_25036524 0.898 Nrarp
Notch-regulated ankyrin repeat protein
chr7_-_106844083 0.893 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr8_-_71601126 0.890 Slc18a1
solute carrier family 18 (vesicular monoamine), member 1
chr11_-_70465629 0.889 Pfn1
profilin 1
chr17_-_34875879 0.885 C4b
complement component 4B (Childo blood group)
chr11_+_93905557 0.873 Spag9
sperm associated antigen 9
chr10_+_101621491 0.863 NM_001162368
Mgat4c
4930402I19Rik
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
RIKEN cDNA 4930402I19 gene
chr2_-_3339919 0.852 NM_008579
Meig1
meiosis expressed gene 1
chr7_+_20101391 0.825


chr4_-_116312481 0.824 Akr1a4
aldo-keto reductase family 1, member A4 (aldehyde reductase)
chr12_-_52847096 0.818 Hectd1
HECT domain containing 1
chr11_+_29592946 0.808 Rtn4
reticulon 4
chr1_-_141982814 0.803 Cfh
complement component factor h
chr7_-_150927867 0.793 NM_024289
Osbpl5
oxysterol binding protein-like 5
chr16_+_4741612 0.784 NM_010443
Hmox2
heme oxygenase (decycling) 2
chr6_-_3444484 0.771 NM_178899
Hepacam2
HEPACAM family member 2
chr10_+_60552061 0.769 NM_025273
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr1_-_172906094 0.764 NM_001077189
NM_010187
Fcgr2b

Fc receptor, IgG, low affinity IIb

chr2_+_174170886 0.742 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr14_-_21437545 0.740 NM_030180
Usp54
ubiquitin specific peptidase 54
chr9_+_92502908 0.719 Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr4_-_116312569 0.717 Akr1a4
aldo-keto reductase family 1, member A4 (aldehyde reductase)
chr9_-_110649625 0.716 NM_011199
Pth1r
parathyroid hormone 1 receptor
chr10_+_59747208 0.708 NM_001146124
Psap
prosaposin
chr4_-_40886191 0.707 Bag1
BCL2-associated athanogene 1
chr18_+_11997728 0.704 NM_001146287
NM_022021
Cables1

CDK5 and Abl enzyme substrate 1

chr17_-_31281223 0.699 NM_009363
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr14_+_103912557 0.697 NM_022886
Scel
sciellin
chr15_-_82169203 0.697 NM_008669
Naga
N-acetyl galactosaminidase, alpha
chr3_-_84063605 0.691 Trim2
tripartite motif-containing 2
chr10_+_18246228 0.678 Nhsl1
NHS-like 1
chr3_-_75073981 0.678 NM_026460
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr1_-_36758359 0.663 Actr1b
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr8_-_73905790 0.648 NM_010150
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr2_+_35413977 0.644 NM_001114125
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr1_-_173177236 0.643 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr7_+_72789752 0.643 NM_172310
Tarsl2
threonyl-tRNA synthetase-like 2
chr11_+_29593657 0.616 NM_194051
Rtn4
reticulon 4
chr3_+_95392919 0.615 Golph3l
golgi phosphoprotein 3-like
chr4_-_141154138 0.613 Fblim1
filamin binding LIM protein 1
chr1_-_195068455 0.601 NM_001044751
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chrX_+_147024463 0.599 NM_008824
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_+_115761660 0.595 Lrrc41
leucine rich repeat containing 41
chr19_+_7495023 0.590 2700081O15Rik
RIKEN cDNA 2700081O15 gene
chr2_+_101726413 0.589 NM_029635
Commd9
COMM domain containing 9
chr2_+_31804066 0.589 1110064A23Rik
RIKEN cDNA 1110064A23 gene
chr16_-_18407565 0.575 Comt
catechol-O-methyltransferase
chr6_+_70676803 0.567


chr4_+_115769086 0.566 Lrrc41
leucine rich repeat containing 41
chr7_-_148462649 0.565 NM_001114322
NM_028069
Cdhr5

cadherin-related family member 5

chr19_+_34175422 0.552 NM_023903
Lipm
lipase, family member M
chr3_+_95392855 0.541 NM_001177669
NM_001177670
NM_146133
Golph3l


golgi phosphoprotein 3-like


chr12_-_86682028 0.541


chr4_+_139204697 0.538 Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr17_+_37035062 0.536 NM_146077
Trim31
tripartite motif-containing 31
chr4_+_98860586 0.534 NM_175029
Atg4c
autophagy-related 4C (yeast)
chr5_+_123526279 0.522 NM_001039723
Tmem120b
transmembrane protein 120B
chr17_-_26335980 0.514 NM_001081070
Pdia2
protein disulfide isomerase associated 2
chr7_-_149865451 0.511 NM_001185083
NM_001185084
NM_008387
Ins2


insulin II


chr2_-_32111045 0.511 Uck1
uridine-cytidine kinase 1
chr4_+_53838895 0.510 NM_028053
Tmem38b
transmembrane protein 38B
chr5_+_3236388 0.504 Gm15772
ribosomal protein L26 pseudogene
chr9_-_48413097 0.499 Nnmt
nicotinamide N-methyltransferase
chr9_+_78078473 0.483 NM_008181
Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr5_+_31179203 0.483 Tmem214
transmembrane protein 214
chr7_-_135137189 0.480 Pycard
PYD and CARD domain containing
chr3_-_88058593 0.476 NM_021375
Rhbg
Rhesus blood group-associated B glycoprotein
chr19_-_32285445 0.471 NM_001168526
Sgms1
sphingomyelin synthase 1
chr9_+_78078492 0.459 Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr13_-_61671425 0.458 NM_026906
Cts3
cathepsin 3
chr7_-_125676823 0.450 NM_009940
Coq7
demethyl-Q 7
chr8_+_74662546 0.447 Tpm4
tropomyosin 4
chr7_-_126602780 0.446 NM_025989
Gp2
glycoprotein 2 (zymogen granule membrane)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.09 3.72e-03 GO:0042221 response to chemical stimulus
2.46 3.39e-02 GO:0009888 tissue development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.20 4.86e-05 GO:0005576 extracellular region
2.66 1.82e-04 GO:0044421 extracellular region part
1.54 2.04e-04 GO:0044444 cytoplasmic part
2.94 2.71e-04 GO:0005615 extracellular space
1.37 6.52e-04 GO:0005737 cytoplasm
21.85 4.69e-03 GO:0005865 striated muscle thin filament
3.79 7.69e-03 GO:0015629 actin cytoskeleton
3.49 1.82e-02 GO:0005792 microsome
3.40 2.36e-02 GO:0042598 vesicular fraction
3.58 2.62e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
8.59 1.32e-05 GO:0019838 growth factor binding
27.32 2.06e-03 GO:0048407 platelet-derived growth factor binding
1.26 4.49e-03 GO:0005488 binding